Infants who had systemic blood infections had alterations in their metabolism

This video presents our systematic review of studies investigating metabolic responses in infants with systemic blood infections, compared with healthy infants.

Publications up to January 2021 were reviewed and four case‐control studies with 78 neonates were included.

Infants with systemic blood infections showed alterations in the glucose and lactate metabolism. They also showed signs of increased oxidative stress and fatty acid oxidation.

However, larger studies are needed to validate the metabolomic signatures in neonatal sepsis.