New medicine can stop autoimmune disease in mice
A new substance causes the immune system to stop attacking its own cells. An experiment with mice now shows that the drug prevented diseases similar to arthritis and type 1 diabetes.
Hospitals were about to run out of other test kits, but the crisis was averted thanks to Magnar Bjørås, professor at the Norwegian University of Science and Technology NTNU, and his team. Now he's being awarded for his role in developing a Covid-test in an unprecedented short period of time.
“Lots of people are being given vaccines over a very short period, so it’s important to monitor them and follow what’s happening,” says Gunnar Fløan Rimul from the Norwegian Medicines Agency.
Just under 29 per cent of respondents in a study said they experienced the same type of mild side effects after the first dose of a Pfizer vaccine, compared to 75,7 per cent of those who had a shot of AstraZeneca.
That a high dosage of adenovirus in the bloodstream could lead to clotting, low levels of platelets and antibodies to platelets was known 20 years ago from animal studies in gene therapy.
Intellectual disabilities can be due to genetic defects that interfere with the absorption of nutrients. Two Norwegian brothers with this condition were saved by a dietary supplement with betaine, a substance found in beets.
“These findings could potentially indicate that the adenovirus-vectored vaccine leads to bleeding disorders not only in rare cases”, Norwegian researchers write in an unpublished study.
“Our theory that this is a powerful immune response most likely triggered by the vaccine, has been confirmed”, says professor and chief physician Pål Andre Holme. Three Norwegian health workers under the age of 50 have been hospitalized. One is dead.
Norwegian clinical experts are investigating whether the vaccine caused an unexpected immune reaction in three health workers who fell ill. No causal connection has been established.