Job description

One position as Post-Doctoral Research Fellow is available for 3 years at the Institute of Basic Medical Sciences, Department of Molecular Medicine, Division of Anatomy. The Department of Molecular Medicine conducts research on basic mechanisms of normal cell and organ function, and of disease development.

More about the position

Applications are invited for a Postdoctoral position financed by the Norwegian Cancer Society. The announced position will be attached to the molecular immunology group, led by Professor Anne Spurkland. The group is focusing on genes controlling T cell activation

https://www.med.uio.no/imb/english/research/groups/immunobiolab/tcell-autoimmune-disease/index.html

The current project will examine how the Lck adapter TSAd (SH2D2A) affects signalling in activated and experienced T cells. The successful candidate will investigate the interactome of TSAd and explore whether the Lck-TSAd interaction affects chimeric antigen receptor (CAR) signalling in T cells. The work will involve affinity purification mass-spectrometry analysis, gene editing of immune cells using CRISPR-Cas9 and generation and analysis of CARs. The research project is thus within the field of immunology and cellular signalling, and candidates with background in these areas will have an advantage. The project may lead to improved cancer immunotherapy using CAR-T cells.

The main purpose of post-doctoral research fellowships is to qualify researchers for work in higher academic positions within their discipline.

We are looking for highly motivated and competent candidates with expertise in cellular and molecular immunology with the personal prerequisites to carry out the project within the given timeframe.

Qualification requirements

• Applicants must hold a degree equivalent to a Norwegian doctoral degree in cellular or molecular immunology. Doctoral dissertation must be submitted for evaluation by the closing date. Appointment is dependent on the public defence of the doctoral thesis being approved.
• Experience with various biochemistry techniques to study cellular signaling
• Fluent oral and written communication skills in English

• The following qualifications will count in the assessment of the applicants:
• Experience in cell analysis by flowcytometry including phosphoflowcytometry
• Experience with CRISPR-Cas9 gene editing in immune cells
• Documented administrative experience, including organizing seminars
• Experience with handling transgenic animals and in isolating and analyzing immune cells from mice
• Good knowledge in standard techniques like cloning and handling of plasmids, mutagenesis of plasmids, gene transfection

Personal skills

Personal suitability and co-operation skills will receive special attention in the selection process.

We offer

• salary NOK 523 200 – 586 900 per annum depending on qualifications in position as Postdoctoral Research Fellow (position code 1352)
• a professionally stimulating working environment
• attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities

How to apply

The application must include

• Application letter describing how she/he fits the description of the person we seek, including a summary of the applicant's scientific work and interests
• CV summarizing education, positions held, details of academic work, pedagogical and administrative documentation of experience and other qualifying activities
• List of publications, published abstracts, presentations that the applicant wishes to be considered by the evaluation committee
• Copies of educational certificates and transcripts of records
• Names and contact details of 2-3 referees stating relation to candidate, e-mail and telephone number
• The application with attachments must be delivered in our electronic recruiting system. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).
• Top applicants will be called in for an interview.

Formal regulations

Please see the guidelines and regulations for appointments to Postdoctoral fellowships at the University of Oslo.

No one can be appointed for more than one Postdoctoral Fellow period at the University of Oslo.

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.

The University of Oslo aims to achieve a balanced gender composition in the workforce and to recruit people with ethnic minority backgrounds.

Contact information

• Professor Anne Spurkland email: anne.spurkland@medisin.uio.no

Apply for position